"They are systematically setting up the most decisive confrontation that we've ever seen," the leading Republican politician told The Jerusalem Post, referring to news reports about the administration's approach to the Israeli-Palestinian conflict.

"There's almost an eagerness to take on the Israeli government to make a point with the Arab world," he said, speaking to the Post ahead of his speech before the American Israel Public Affairs Committee's annual conference.

He called US President Barack Obama's program of engagement on Iran a "fantasy," and his Middle East policies "very dangerous for Israel." He summed up Obama's approach as "the clearest adoption of weakness since Jimmy Carter."